Dissection of a Protein Transporter Essay Example | Topics and Well Written Essays - 1000 words

Dissection of a Protein Transporter - Essay ExampleThis will shed light on understanding head pathways and how these target pathways contribute to the overall translocation of proteins a soft touch the ER membrane. This also helps in identifying novel components for particular specific pathways and components usual for all pathways. Mitochondrial proteins tend to be nuclear encoded and these proteins must be translocated to the compartments within the mitochondria (Copley, 1997 Berg 2002). The final placement is determined with interaction of nascent polypeptides with inner and outer membrane translocation complexes.Protein synthesis tends to occur in cytosols and in mitochondria, chloroplasts and the location of proteins and crossing of proteins across plasma membrane could be studied using the concept of protein translocation. This undertake is based on the discussion of protein translocation and the mechanism involved in such translocation including the reasons why proteins se em to cross membranes and whether it is done as chains or after folding.The translocation of proteins was first experimentally discovered by Blobel in 1970 and he discovered that proteins tend to have signal sequence or a short amino group acid sequence and this functions as a code address for the target organelle. mRNA translates into protein with the help of a ribosome and this process of translation takes place within the cytosol (Agarraberes and Dice, 2001, Berg, 2002). When synthesized proteins belong to specific organelles they can be transported through cotranslational translocation or posttranslational translocation. In the cotranslational translocation, the N terminal signal sequence is recognised by a signal mention particle or SRP at the time when the protein is being synthesized on the ribosome (Agarraberes and Dice, 2001 Berg, 2002). The ribosome protein complex is transferred to the SRP receptor on the endoplasmic reticulum and the nascent protein is inserted in the translocation complex and passes